Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype.

Abstract

GH-3 is an established cell line which, for the production of both PRL and GH, may be related to the bipotential somatomammotroph from which both somatotroph and mammotroph cells derive. In the present study we first report that GH-3 cells express both the gp140trk and the gp75 components of the nerve growth factor (NGF) receptor and that NGF dictates a… (More)

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Cite this paper

@article{Missale1994NerveGF, title={Nerve growth factor directs differentiation of the bipotential cell line GH-3 into the mammotroph phenotype.}, author={Cristina Missale and Flora Boroni and Sandra Sigala and Artur Zanellato and Roberto Dal Toso and Andrea Balsari and Pier Franco Spano}, journal={Endocrinology}, year={1994}, volume={135 1}, pages={290-8} }