Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion.

@article{Salas2006NerveGF,
  title={Nerve growth factor-dependent activation of trkA receptors in the human ovary results in synthesis of follicle-stimulating hormone receptors and estrogen secretion.},
  author={Cristian Salas and Marcela Julio-Pieper and Macarena Valladares and Ricardo Pommer and Margarita Vega and Claudio Mastronardi and Bredford Kerr and Sergio R. Ojeda and Hern{\'a}n E. Lara and Carmen Carrascosa Romero},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2006},
  volume={91 6},
  pages={2396-403}
}
CONTEXT Previous studies showed that nerve growth factor (NGF) induces the expression of functional FSH receptors (FSHR) in preantral follicles of the developing rat ovary. OBJECTIVE The objective of this study was to determine whether NGF can affect granulosa cell (GC) function in human periovulatory follicles using intact human ovaries and isolated human GCs. PATIENTS AND INTERVENTIONS Human GCs were obtained from in vitro fertilization patients and normal ovaries from women with elective… CONTINUE READING