Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism.

@article{Missale1996NerveGF,
  title={Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism.},
  author={Cristina Missale and Marco Losa and Sandra Sigala and Andrea Balsari and Massimo Giovanelli and PierFranco Spano},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 3},
  pages={272-85}
}
Two different human prolactinoma phenotypes (responders and nonresponders), which are distinguished by different tumorigenic potential and different responsiveness to dopaminergic therapy, have recently been identified. Responders show low proliferation rate, low tumorigenic potential, and expression of D-2 receptors for dopamine (DA), while nonresponders are characterized by high proliferation rate, high tumorigenic potential, and lack of expression of DA D-2 receptors. In this study it has… CONTINUE READING

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