Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis.

@article{Toyoda2002NerveGF,
  title={Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis.},
  author={Masahiko Toyoda and Motonobu Nakamura and Takamitsu Makino and Tadashi Hino and Masayori Kagoura and M. Morohashi},
  journal={The British journal of dermatology},
  year={2002},
  volume={147 1},
  pages={71-9}
}
BACKGROUND Neurogenic components, such as neurotrophic factors and neuropeptides, are probably involved in the pathogenesis of atopic dermatitis (AD) via the neuroimmunocutaneous system. Numerous in vitro and in vivo studies have shown that nerve growth factor (NGF), the best-characterized member of the neurotrophin family, modulates the synthesis of the neuropeptide substance P (SP), both of which may be associated with the pathogenesis of human allergic diseases. OBJECTIVES To evaluate the… CONTINUE READING