Nerve fibres are required to evoke a contact sensitivity response in mice.

@article{Beresford2004NerveFA,
  title={Nerve fibres are required to evoke a contact sensitivity response in mice.},
  author={Lorna J Beresford and Oliver Orange and Eric B. Bell and Jaleel Ahmad Miyan},
  journal={Immunology},
  year={2004},
  volume={111 1},
  pages={118-25}
}
Previous work has indicated that the dermis and epidermis of skin contains abundant nerve fibres closely associated with Langerhans' cells. We have investigated whether these nerve endings are necessary for inducing and evoking a contact sensitivity (CS) response. Topical application of a general or a peptide (calcitonin gene-related peptide and substance P)-specific neurotoxin was employed to destroy the nerve fibres at skin sites subsequently used to induce or evoke the CS response… CONTINUE READING

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