Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

@article{Kardos1989NerveEF,
  title={Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability},
  author={J. Kardos and I. Kov{\'a}cs and F. Haj{\'o}s and M. K{\'a}lm{\'a}n and M. Simonyi},
  journal={Neuroscience Letters},
  year={1989},
  volume={103},
  pages={139-144}
}
  • J. Kardos, I. Kovács, +2 authors M. Simonyi
  • Published 1989
  • Chemistry, Medicine
  • Neuroscience Letters
  • Membrane vesicles from rat cerebral cortex were prepared and the functional response of the GABAA receptor was followed by monitoring GABA-activated influx of the radiotracer 36Cl- ion. CuCl2 decreased GABA-activated 36Cl- influx into synaptosomal membrane vesicles. The effect of Cu2+ was concentration dependent (5-500 microM CuCl2) and occurred with saturating (1 mM) as well as low (30 microM) GABA concentrations. A similar inhibition of the responses to muscimol (30 microM) was also observed… CONTINUE READING
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