Nerve control of type 2A MHC isoform expression in regenerating slow skeletal muscle.

@article{Megighian2001NerveCO,
  title={Nerve control of type 2A MHC isoform expression in regenerating slow skeletal muscle.},
  author={Aram Megighian and Elena Germinario and Katia Rossini and Menotti Midrio and Daniela Danieli-Betto},
  journal={Muscle & nerve},
  year={2001},
  volume={24 1},
  pages={47-53}
}
Bupivacaine-induced regeneration was studied in rat soleus muscle under several conditions, with the focus on type 2A and type 1 myosin heavy chain (MHC) isoform expression. In denervated muscles, type 1 was absent, whereas type 2A was widely expressed, a pattern of regeneration which appeared to be independent of fibrillation activity of the muscle. Both type 1 and type 2A isoforms were absent in muscles regenerated during tetrodotoxin (TTX) block of impulse conduction in the sciatic nerve… CONTINUE READING