Nerve conduction studies in the Twitcher mouse (murine globoid cell leukodystrophy).

@article{Toyoshima1986NerveCS,
  title={Nerve conduction studies in the Twitcher mouse (murine globoid cell leukodystrophy).},
  author={Eri Toyoshima and Andrew M. Yeager and Sean Brennan and George W. Santos and Hugo W. Moser and Richard F. Mayer},
  journal={Journal of the neurological sciences},
  year={1986},
  volume={74 2-3},
  pages={307-18}
}
Progression of the neuropathy in the Twitcher mouse (twi-C57BL/6J), an animal model of globoid cell leukodystrophy, was assessed with serial motor nerve conduction studies from just after birth until near death (day 45) and after hematopoietic cell transplantation (HCT). Under ether anesthesia, the tibial nerve was stimulated percutaneously at the sacral notch and at the ankle, and recordings were made from plantar foot muscles. Motor conduction velocity (MCV), distal latency, amplitude… CONTINUE READING