Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.

@article{Dunn2001NerveAM,
  title={Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.},
  author={Shannon E. Dunn and Alain R Simard and Rhonda Bassel-Duby and R. Sanders Williams and Robin N. Michel},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 48},
  pages={45243-54}
}
This study tested the hypothesis that calcineurin signaling is modulated in skeletal muscle cells by fluctuations in nerve-mediated activity. We show that dephosphorylation of NFATc1, MEF2A, and MEF2D transcription factors by calcineurin in all muscle types is dependent on nerve activity and positively correlated with muscle usage under normal weightbearing conditions. With increased nerve-mediated activity, calcineurin dephosphorylation of these targets was found to be potentiated in a way… CONTINUE READING