Nerve Growth Factor-induced Changes in the Intracellular Localization of the Protein Kinase C Substrate B-50 in Pheochromocytoma PC 12 Cells

@inproceedings{Hooff2002NerveGF,
  title={Nerve Growth Factor-induced Changes in the Intracellular Localization of the Protein Kinase C Substrate B-50 in Pheochromocytoma PC 12 Cells},
  author={Carien O. M. Van Hooff and Joost C M Holthuis and AB. Oestreicher and N. E.V.},
  year={2002}
}
High levels of the neuron-specific protein kinase C substrate, B-50 (= GAP43), are present in neurites and growth cones during neuronal development and regeneration. This suggests a hitherto nonelucidated role of this protein in neurite outgrowth. Comparable high levels of B-50 arise in the pheochromocytoma PC12 cell line during neurite formation. To get insight in the putative growthassociated function of B-50, we compared its ultrastructural localization in naive PC12 cells with its… CONTINUE READING
5 Citations
56 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Altered distribution of immunoreactivity for the growth-associated protein B-50 in neuritic

  • A. W. Clark, P. Tran, S. Aubin, H. Zwiers
  • The Journal of Cell Biology,
  • 1988
1 Excerpt

Caisiosome', a cytoplasmic organelle: the inosi~

  • D. P. Lew
  • 1988

Licht and electron microscopical study

  • nekens, W. H. Gispen
  • 1988

Similar Papers

Loading similar papers…