• DOI:10.1097/00002826-199114001-00008
Corpus ID: 45315301

Nerve Growth Factor and Alzheimer's Disease

@article{Hefti1986NerveGF,
  title={Nerve Growth Factor and Alzheimer's Disease},
  author={F. Hefti and L. Schneider},
  journal={Clinical Neuropharmacology},
  year={1986},
  volume={14},
  pages={S62–S76}
}

F. Hefti, L. Schneider

Published 1986

Psychology, Medicine

Clinical Neuropharmacology

Summary: Clinical trials with cholinergic agents suggest that cholinergic hypertrophy may be beneficial in the treatment of Alzheimer's disease (AD). Recent findings substantiate the view that nerve growth factor (NGF) selectively acts on cholinergic neurons. In adult rats and primates, intraventricular administration of nerve growth factor produces trophic actions on cholinergic neurons and prevents age related neuronal atrophy. These findings suggest the possibility of the eventual… CONTINUE READING

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