Nerve Growth Factor and Alzheimer's Disease

  title={Nerve Growth Factor and Alzheimer's Disease},
  author={F. Hefti and L. Schneider},
  journal={Clinical Neuropharmacology},
Summary: Clinical trials with cholinergic agents suggest that cholinergic hypertrophy may be beneficial in the treatment of Alzheimer's disease (AD). Recent findings substantiate the view that nerve growth factor (NGF) selectively acts on cholinergic neurons. In adult rats and primates, intraventricular administration of nerve growth factor produces trophic actions on cholinergic neurons and prevents age related neuronal atrophy. These findings suggest the possibility of the eventual… Expand
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