Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins

@inproceedings{Spencer2017NerveGF,
  title={Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins},
  author={Ambre Spencer and Lingli Yu and Vincent Guili and Florie Reynaud and Yindi Ding and Ji Jie Ma and J{\'e}r{\^o}me Jullien and David Koubi and Emmanuel Gauthier and David Cluet and Julien Falk and Val{\'e}rie Castellani and Chonggang Yuan and Brian B. Rudkin},
  booktitle={International journal of molecular sciences},
  year={2017}
}
Membrane microdomains or "lipid rafts" have emerged as essential functional modules of the cell, critical for the regulation of growth factor receptor-mediated responses. Herein we describe the dichotomy between caveolin-1 and caveolin-2, structural and regulatory components of microdomains, in modulating proliferation and differentiation. Caveolin-2 potentiates while caveolin-1 inhibits nerve growth factor (NGF) signaling and subsequent cell differentiation. Caveolin-2 does not appear to… CONTINUE READING
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