Neprilysin gene transfer: A promising therapeutic approach for Alzheimer's disease.

  title={Neprilysin gene transfer: A promising therapeutic approach for Alzheimer's disease.},
  author={Yuanli Li and Junqing Wang and Shenghao Zhang and Zhaohui Liu},
  journal={Journal of neuroscience research},
  volume={93 9},
Alzheimer's disease (AD) is characterized by widespread neurodegeneration throughout the association cortex and limbic system, deposition of amyloid-β (Aβ) in the neuropil and around blood vessels, and formation of neurofibrillary tangles. Aβ accumulation is considered the major pathological change in AD progression. In recent years, several therapeutic strategies for treating AD have focused on reducing the Aβ burden in the brain. Among these approaches, the expression of Aβ-degrading enzymes… CONTINUE READING
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