Neprilysin-2 is an important β-amyloid degrading enzyme.

  title={Neprilysin-2 is an important β-amyloid degrading enzyme.},
  author={Daniel M. Hafez and Jeffrey Y Huang and Alexis M. Huynh and Stephanie Valtierra and Edward M. Rockenstein and Angela M. Bruno and Bao Shi Lu and Luc Desgroseillers and Eliezer Masliah and Robert A. Marr},
  journal={The American journal of pathology},
  volume={178 1},
Proteases that degrade the amyloid-β peptide (Aβ) are important in protecting against Alzheimer's disease (AD), and understanding these proteases is critical to understanding AD pathology. Endopeptidases sensitive to inhibition by thiorphan and phosphoramidon are especially important, because these inhibitors induce dramatic Aβ accumulation (∼30- to 50-fold) and pathological deposition in rodents. The Aβ-degrading enzyme neprilysin (NEP) is the best known target of these inhibitors. However… CONTINUE READING

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