Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination.

  title={Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination.},
  author={Matthew Bidwell Goetz and Jeffrey Sayers},
  journal={The Journal of antimicrobial chemotherapy},
  volume={32 2},
There is conflict by evidence as to whether therapy with vancomycin plus an aminoglycoside is more nephrotoxic than therapy with either agent alone. Here we report the results of a prospective, non-randomized, open-label study of the incidence of nephrotoxicity in elderly patients who received vancomycin alone (32 patients) or an aminoglycoside alone (67 patients) or in combination (37 patients). The mean (95% confidence limits) incidence of nephrotoxicity, defined as an increase of > or = 44.2… CONTINUE READING

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