Nephrotoxicity of cyclosporine A in rats with a diminished renal function.

@article{Provoost1986NephrotoxicityOC,
  title={Nephrotoxicity of cyclosporine A in rats with a diminished renal function.},
  author={Abraham P. Provoost and L C Kaptein and M. L. van Aken},
  journal={Clinical nephrology},
  year={1986},
  volume={25 Suppl 1},
  pages={S162-7}
}
We have studied the effect of cyclosporine A (CyA) in male Wistar rats with only one kidney, that had been subjected to 45 min of warm ischemia (IS + NX). The effects were compared with those obtained in rats with either one (NX) or two intact kidneys (2K). Vehicle treated rats that underwent the same surgical procedure served as controls. The GFR and the ERPF were determined during and after the treatment period. The CyA was administered i.m. daily for a period of 5 days a week for a period of… CONTINUE READING