Nephrotoxicity of cadmium & lead.

  title={Nephrotoxicity of cadmium & lead.},
  author={Harvey Craig Gonick},
  journal={The Indian journal of medical research},
  volume={128 4},
Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. The pathophysiological results, however, tend to diverge. Cadmium in sufficient cumulative dosage leads to the production of the Fanconi syndrome, a generalized proximal tubular reabsorptive defect thought to be related to inhibition of both ATP production and Na-K-ATPase activity. On the other hand, lead accumulation in the proximal tubule leads to hyperuricaemia… CONTINUE READING


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