Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention

@article{Tune1997NephrotoxicityOB,
  title={Nephrotoxicity of beta-lactam antibiotics: mechanisms and strategies for prevention},
  author={Bruce M. Tune},
  journal={Pediatric Nephrology},
  year={1997},
  volume={11},
  pages={768-772}
}
  • B. Tune
  • Published 1 December 1997
  • Biology, Medicine
  • Pediatric Nephrology
The nephrotoxic beta-lactam antibiotics cause acute proximal tubular necrosis. Significant renal toxicity, which has been rare with the penicillins and uncommon with the cephalosporins, is a greater risk with the penems. Mechanisms of injury include: (1) transport into the tubular cell, mainly through the antiluminal organic anion secretory carrier; (2) acylation of target proteins, causing respiratory toxicity by inactivation of mitochondrial anionic substrate carriers; and (3) lipid… 
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