Nephrotoxicity of 4-cycloocten-1-carbaldehyde

  title={Nephrotoxicity of 4-cycloocten-1-carbaldehyde},
  author={Horst Messinger and Marcus Kleber and Walter Aulmann},
  journal={Archives of Toxicology},
Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitization, subchronic toxicity, and mutagenicity. The substance was strongly irritating to the skin but only weakly irritating to the eye. It gave a clear indication of having skin… 



Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S-yl)hydroquinone.

Pretreatment of rats with acivicin prevents hydroquinone-mediated nephrotoxicity, indicating that toxicity is dependent on the formation of metabolites that require processing by gamma-GT and metabolic data indicate a role for hydroquin one-thioether metabolites in Hydroquinone toxicity and carcinogenicity.

Comparison of the Subacute Nephrotoxicity of Industrial Solvents in the Rat

The effects on the urinary excretion of albumin, s2-microglobulin (s2–m) and s-N-acetylglucosaminidase of the most widely used industrial solvents when subacutely administered to female Sprague-Dawley rats are compared.

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro : implications for prediction of metabolic interactions in vivo

The results indicate that animal models may have a limited role in the extrapolation to patients of drug interactions with agents such as DMXAA that have immunomodulating activity that may vary widely between species.

Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice.

Malignant lymphoma occurred with a positive trend and was significantly greater than controls in female mice in the 2,000 ppm group and within the NTP historical control range and could not be clearly related to citral administration.

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  • R. Czerniak
  • Biology
    International journal of toxicology
  • 2001
It is shown that the fundamental PK parameters of clearance (CL) and volume (V) can demonstrate a gender dependence in a wide variety of animal species: rats, mice, rabbits, hamsters, dwarf goats, cattle, and rainbow trout.

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