Nephrotoxicity and the proximal tubule. Insights from cadmium.

  title={Nephrotoxicity and the proximal tubule. Insights from cadmium.},
  author={Frank Th{\'e}venod},
  journal={Nephron. Physiology},
  volume={93 4},
Cadmium (Cd(2+)) is a non-essential heavy metal, which is taken up from the environment into the body through pulmonary and enteral pathways. The S1 segment of the kidney proximal tubule (PT) is a major target of chronic Cd(2+) toxicity. Renal dysfunction develops in up to 7% of the general population and in its most severe form displays major features of… CONTINUE READING