Nephrotoxicity and pharmacokinetics of cisplatinum in young and adult rats.

  title={Nephrotoxicity and pharmacokinetics of cisplatinum in young and adult rats.},
  author={Dorothea Appenroth and Klaus Winnefeld and Helmut Br{\"a}unlich},
  journal={Biomedica biochimica acta},
  volume={47 8},
Wistar rats (10 and 55 days old) were administered a single dose of 0.6 mg cisplatinum (CP) 100 g body wt. intraperitoneally. Urinary volume, p-aminohippurate and total protein excretion were determined. Separation of urinary proteins was performed by sodium dodecylsulfate polyacrylamide gel electrophoresis. Significant symptoms of nephrotoxicity (oliguria, reduced PAH-excretion, heavy proteinuria, changes in urinary protein composition) were detected in adult rats 72 h after CP. At that time… CONTINUE READING
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