Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide

  title={Nephrotoxicity and neurotoxicity in humans from organogermanium compounds and germanium dioxide},
  author={Alexander G. Schauss},
  journal={Biological Trace Element Research},
There is no known biological requirement for germanium (Ge), germanates, or any organogermanium compound. Ge deficiency has not been demonstrated in any animal. The estimated average dietary intake of Ge in humans is 1.5 mg/d. Ge is widely distributed in edible foods, all of which, with few exceptions, contain less than 5 ppm Ge, since higher levels are toxic to most plants. Ingestion of Ge compounds has been shown to produce toxic effects in experimental animals. In recent years inorganic… CONTINUE READING
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