Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice.

@article{Torti2001NephrotoxicityAH,
  title={Nephrotoxicity and hepatotoxicity induced by inhaled bromodichloromethane in wild-type and p53-heterozygous mice.},
  author={Vincent R Torti and Alison J Cobb and Jeffrey I Everitt and Marianne W Marshall and Gary A. Boorman and Byron E. Butterworth},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={64 2},
  pages={269-80}
}
Bromodichloromethane (BDCM) is a common municipal drinking water disinfection by-product, resulting in widespread trace human exposure via ingestion and inhalation. The present studies were designed to define organ-specific, BDCM-induced toxicity in wild type (p53(+/+)) and heterozygous (p53(+/-)) mice on both the FVB/N and C57BL/6 genetic backgrounds. Mice were exposed to BDCM vapor daily for 6 h/day and 7 days/week at concentrations of 0, 1, 10, 30, 100, or 150 ppm for 1 week and at 0, 0.3, 1… CONTINUE READING