Nephrotoxicity Related to New Therapeutic Compounds

@article{Szeto2005NephrotoxicityRT,
  title={Nephrotoxicity Related to New Therapeutic Compounds},
  author={Cheuk Chun Szeto and Kai Ming Chow},
  journal={Renal Failure},
  year={2005},
  volume={27},
  pages={329 - 333}
}
Toxic nephropathy is an important cause of reversible renal injury. This article focuses on the nephrotoxicity of several new therapeutic compounds. Selective cyclooxygenase-2 inhibitor is associated with sodium retention, hypertension, ankle edema, and acute renal failure. The incidence of renal complication is similar to conventional nonsteroidal anti-inflammatory drugs. Bisphosphonates, especially when used in high dose for prolonged duration, can cause toxic acute tubular necrosis and renal… 
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Current approaches on the development of three-dimensional and microfluidic models and recently developed stem cell based approaches are reviewed, showing that high predictivity can be obtained by using primary or stem cell derived human renal cells in combination with appropriate end points.
Target Sites: Kidney
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References

SHOWING 1-10 OF 24 REFERENCES
Crystal-induced acute renal failure.
Toxic acute tubular necrosis following treatment with zoledronate (Zometa).
TLDR
The close temporal relationship between zoledronate administration and the onset of renal failure and the partial recovery of renal function following drug withdrawal strongly implicate this important and widely used agent in the development of toxic ATN.
Crystalluria and Urinary Tract Abnormalities Associated with Indinavir
TLDR
A spectrum of urinary tract findings in patients treated with indinavir is reported, most common is asymptomatic crystalluria associated with dysuria, urgency, back and flank pain, and renal colic, while some patients with back or flank pain had radiographic evidence of renal parenchymal defects.
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion.
TLDR
It is concluded that adefovir-induced nephrotoxicity is mediated by depletion of mt DNA from proximal tubular cells through inhibition of mtDNA replication, which may serve as a prototype for other forms of renal toxicity caused by reverse transcriptase inhibitors.
Renal safety and tolerability of celecoxib, a novel cyclooxygenase-2 inhibitor.
TLDR
It is concluded that celecoxib is well tolerated by patients who may be at risk for NSAID-induced renal toxicity, such as the elderly and those with hypertension or preexisting chronic heart disease, and there was no evidence of drug-drug interactions between cele Coxib and concomitant angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, calcium channel blockers, or diuretics.
Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate.
TLDR
The temporal association between pamidronate therapy and the development of renal insufficiency, the use of escalating doses that exceed recommended levels, and the distinctive pattern of glomerular andtubular injury strongly suggest a mechanism of drug-associated podocyte and tubular toxicity.
Renal insufficiency after intravenous immune globulin therapy: a report of two cases and an analysis of the literature.
TLDR
Two cases of IVIG-induced ARF are described, and all reported cases are analyzed to assess the probable mechanism of renal injury.
Prospective study of urinalysis abnormalities in HIV-positive individuals treated with indinavir.
TLDR
The main findings were the high proportion of subjects with crystalluria and the relatively high frequency of crystalluria observed consistently throughout and abnormal urinalysis results were noted frequently during the first year of treatment with indinavir.
Acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin.
TLDR
A kidney allograft recipient who developed anemia due to parvovirus B19induced erythroaplasia and Therapeutic intervention with IV Ig resulted in acute graft failure requiring transient hemodialysis.
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
TLDR
The data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition ofcox-1.
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