Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.
@article{KellnerWeibel1995NephrotoxicPO, title={Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.}, author={Ginny L. Kellner-Weibel and Ruy Tchao and Peter J. Harvison}, journal={Toxicology letters}, year={1995}, volume={80 1-3}, pages={ 123-9 } }
10 Citations
Comparative disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide and the non-nephrotoxicant N-(3, 5-difluorophenyl)succinimide in Fischer 344 rats.
- Biology, MedicineDrug metabolism and disposition: the biological fate of chemicals
- 1999
NDPS achieves higher tissue and plasma concentrations, covalently binds to a greater extent, and is eliminated more slowly than DFPS, which may contribute to differential toxicity of these analogs.
The effect of aromatic fluorine substitution on the nephrotoxicity and metabolism of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats.
- Chemistry, BiologyToxicology
- 1997
Comparative Disposition of the NephrotoxicantN-(3,5-Dichlorophenyl)Succinimide and the Non-Nephrotoxicant N-(3,5-Difluorophenyl)Succinimide in Fischer 344 Rats
- Biology, Medicine
- 1999
NDPS achieves higher tissue and plasma concentrations, covalently binds to a greater extent, and is eliminated more slowly than DFPS, which may contribute to differential toxicity of these analogs.
In vivo metabolism and disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide in Fischer 344 rats.
- Chemistry, BiologyDrug metabolism and disposition: the biological fate of chemicals
- 1998
Dose-dependent increases in blood urea nitrogen levels, diuresis, proteinuria, glucosuria, and covalent protein adducts correlated with increases in oxidative metabolism, providing additional evidence for the importance of oxidative metabolism in NDPS-induced kidney damage.
Cytochrome P450-mediated metabolism and nephrotoxicity of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats.
- Biology, ChemistryFundamental and applied toxicology : official journal of the Society of Toxicology
- 1997
There was a correlation between pretreatments that induce P450-mediated NDPS metabolism and the effects that these compounds have on NDPS-induced nephrotoxicity, and the data indicate that specific P450 isozymes metabolize NDPS to its hydroxylated products and suggest that these metabolites mediate the neph rotoxicity induced by NDPS.
Cytochrome P 450-Mediated Metabolism and Nephrotoxicity of / V-( 3 , 5-Dichlorophenyl ) succinimide in Fischer 344 Rats
- Biology, Chemistry
- 2005
There was a correlation between pretreatments that induce P450-mediated NDPS metabolism and the effects that these compounds have on NDPS-induced nephrotoxicity, and the data indicate that specific P450 isozymes metabolize NDPS to its hydroxylated products and suggest that these metabolites mediate the neph rotoxicity induced by NDPS.
Nephrotoxic and hepatotoxic potential of imidazolidinedione-, oxazolidinedione- and thiazolidinedione-containing analogues of N-(3,5-dichlorophenyl)succinimide (NDPS) in Fischer 344 rats.
- Biology, ChemistryToxicology
- 2003
NEPHROTOXICITY INDUCED BY C- AND N-ARYLSUCCINIMIDES
- Biology, ChemistryJournal of toxicology and environmental health. Part B, Critical reviews
- 2004
In this review, the structure–nephrotoxicity relationships, biotransformation, and mechanisms of nephrotoxicity for the C- and N-arylsuccinimides are examined.
Removal of dimethachlon from soils using immobilized cells and enzymes of a novel potential degrader Providencia stuartii JD.
- Biology, EngineeringJournal of hazardous materials
- 2019
Final Report of the Safety Assessment of Cosmetic Ingredients Derived From Zea Mays (Corn)
- MedicineInternational journal of toxicology
- 2011
The CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.
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