Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.

@article{KellnerWeibel1995NephrotoxicPO,
  title={Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.},
  author={G. L. Kellner-Weibel and R. Tchao and P. J. Harvison},
  journal={Toxicology letters},
  year={1995},
  volume={80 1-3},
  pages={
          123-9
        }
}
  • G. L. Kellner-Weibel, R. Tchao, P. J. Harvison
  • Published 1995
  • Chemistry, Medicine
  • Toxicology letters
    • The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) produces kidney damage in rats. Although many NDPS analogues have been screened as possible nephrotoxicants, the one-carbon homologue, N-(3,5-dichlorophenyl)glutarimide (NDPG), has not been evaluated. This study examined the nephrotoxic potential of NDPG and a putative metabolite, N-(3,5-dichlorophenyl)glutaramic acid (NDPGA). Male Fischer 344 rats (N = 3-4 per group) were administered a single i.p. injection in corn oil of… CONTINUE READING
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