Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.

@article{KellnerWeibel1995NephrotoxicPO,
  title={Nephrotoxic potential of N-(3,5-dichlorophenyl)glutarimide and N-(3,5-dichlorophenyl)glutaramic acid in Fischer 344 rats.},
  author={Ginny L. Kellner-Weibel and Ruy Tchao and Peter J. Harvison},
  journal={Toxicology letters},
  year={1995},
  volume={80 1-3},
  pages={
          123-9
        }
}
Comparative disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide and the non-nephrotoxicant N-(3, 5-difluorophenyl)succinimide in Fischer 344 rats.
TLDR
NDPS achieves higher tissue and plasma concentrations, covalently binds to a greater extent, and is eliminated more slowly than DFPS, which may contribute to differential toxicity of these analogs.
Comparative Disposition of the NephrotoxicantN-(3,5-Dichlorophenyl)Succinimide and the Non-Nephrotoxicant N-(3,5-Difluorophenyl)Succinimide in Fischer 344 Rats
TLDR
NDPS achieves higher tissue and plasma concentrations, covalently binds to a greater extent, and is eliminated more slowly than DFPS, which may contribute to differential toxicity of these analogs.
In vivo metabolism and disposition of the nephrotoxicant N-(3, 5-dichlorophenyl)succinimide in Fischer 344 rats.
TLDR
Dose-dependent increases in blood urea nitrogen levels, diuresis, proteinuria, glucosuria, and covalent protein adducts correlated with increases in oxidative metabolism, providing additional evidence for the importance of oxidative metabolism in NDPS-induced kidney damage.
Cytochrome P450-mediated metabolism and nephrotoxicity of N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats.
TLDR
There was a correlation between pretreatments that induce P450-mediated NDPS metabolism and the effects that these compounds have on NDPS-induced nephrotoxicity, and the data indicate that specific P450 isozymes metabolize NDPS to its hydroxylated products and suggest that these metabolites mediate the neph rotoxicity induced by NDPS.
Cytochrome P 450-Mediated Metabolism and Nephrotoxicity of / V-( 3 , 5-Dichlorophenyl ) succinimide in Fischer 344 Rats
TLDR
There was a correlation between pretreatments that induce P450-mediated NDPS metabolism and the effects that these compounds have on NDPS-induced nephrotoxicity, and the data indicate that specific P450 isozymes metabolize NDPS to its hydroxylated products and suggest that these metabolites mediate the neph rotoxicity induced by NDPS.
NEPHROTOXICITY INDUCED BY C- AND N-ARYLSUCCINIMIDES
  • G. Rankin
  • Biology, Chemistry
    Journal of toxicology and environmental health. Part B, Critical reviews
  • 2004
TLDR
In this review, the structure–nephrotoxicity relationships, biotransformation, and mechanisms of nephrotoxicity for the C- and N-arylsuccinimides are examined.
Final Report of the Safety Assessment of Cosmetic Ingredients Derived From Zea Mays (Corn)
TLDR
The CIR Expert Panel determined that corn-derived ingredients are safe for use in cosmetics in the practices of use and concentration described in the assessment.

References

SHOWING 1-10 OF 19 REFERENCES
Nephrotoxicity of N-(3,5-dihalophenyl)succinimides in Fischer 344 rats.
TLDR
Results indicate that the halogen species can influence the nephrotoxicity produced by the NDHPS, and neph rotoxic potential did not correlate with fungicidal efficacy, which suggests that the nePhrotoxic and fungicidal mechanisms of these compounds might be different.
Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide by isolated rat hepatocytes.
TLDR
It is demonstrated that isolated hepatocytes can be used to characterize the metabolism of NDPS and may be useful in elucidating the role of the liver in NDPS-induced nephrotoxicity and the formation of glucuronide, sulfate, or glutathione conjugates.
...
...