Nephrotoxic effects of designer drugs: synthetic is not better!
@article{Luciano2014NephrotoxicEO, title={Nephrotoxic effects of designer drugs: synthetic is not better!}, author={Randy L. Luciano and Mark A Perazella}, journal={Nature Reviews Nephrology}, year={2014}, volume={10}, pages={314-324} }
Designer drugs are synthetic, psychoactive substances with similar structures and activity to existing scheduled drugs or controlled chemical compounds. The use of these drugs is not generally considered illegal and they cannot be detected using standard toxicology tests—essentially they are considered to be 'legal highs'. Over the past several years, increasing numbers of designer drugs have become available. These drugs are classified as amphetamine derivatives, phenylpiperazine derivatives…
43 Citations
Synthetic cathinones - From natural plant stimulant to new drug of abuse.
- ChemistryEuropean journal of pharmacology
- 2020
Nephrotoxicity of Combining 2-Phenethylamine and N, N-Dimethyl-β-Phenethylamine
- Biology
- 2016
This work investigated the possible nephrotoxic effects of two naturally occurring compounds: 2-phenethylamine and N, N-dimethyl-β-phenthylamine alone and in combination because they are currently used in dietary supplements presently on the market.
Fatal Poisonings Associated with New Psychoactive Substances.
- MedicineHandbook of experimental pharmacology
- 2018
This chapter describes how new psychoactive substances (NPS) have been involved in fatal intoxications from 2010 and onwards. It summarizes the circumstances, antemortem symptoms, and adverse effects…
The Toxicology of New Psychoactive Substances: Synthetic Cathinones and Phenylethylamines
- Biology, MedicineTherapeutic drug monitoring
- 2016
The acute and chronic toxicity of many NPSs is unknown or very sparsely investigated, and there is a need for evidence-based-treatment recommendations for acute intoxications and a demand for new strategies to analyze these compounds in clinical and forensic cases.
New Drugs of Abuse and Withdrawal Syndromes.
- Psychology, MedicineEmergency medicine clinics of North America
- 2015
Novel psychoactive substances of interest for psychiatry
- Psychology, BiologyWorld psychiatry : official journal of the World Psychiatric Association
- 2015
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine‐like…
Pharmacology behind Common Drug Nephrotoxicities.
- Medicine, BiologyClinical journal of the American Society of Nephrology : CJASN
- 2018
Clinically relevant aspects of drug-induced nephrotoxicity for the clinical nephrologist are reviewed.
The nephrologist's guide to cannabis and cannabinoids
- Medicine, BiologyCurrent opinion in nephrology and hypertension
- 2020
Patients and healthcare professionals have little guidance or evidence regarding the impact of cannabis use on people with kidney disease and this knowledge gap will remain as long as federal regulations remain prohibitively restrictive towards prospective research.
Systematic review of nephrotoxicity of drugs of abuse, 2005–2016
- Medicine, PsychologyBMC Nephrology
- 2017
A wide range of renal manifestations were found to be associated with drug abuse, which will put a significant percentage of the population at an elevated risk for poor renal outcomes.
Acute and delayed nephropathy due to methamphetamine abuse
- Biology, Medicine
- 2019
The effects of methamphetamine on the kidneys can be divided into the following sub-groups: vascular effects, non-traumatic rhabdomyolysis and direct nephrotoxicity.
References
SHOWING 1-10 OF 136 REFERENCES
Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids
- BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 2012
AKI associated with synthetic cannabinoids: a case series.
- MedicineClinical journal of the American Society of Nephrology : CJASN
- 2013
The close temporal and geographic associations between the clinical presentation and the development of AKI strongly suggest an association between these SPICE preparations and AKI, especially in young adults with negative urine drug screens.
Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2
- MedicinePediatrics
- 2011
The first (to the authors' knowledge) cases of myocardial infarction after smoking K2 are reported, and public education and awareness need to be heightened about the possible health implications of K2.
Clinical and pharmacological aspects of bath salt use: a review of the literature and case reports.
- Psychology, MedicineDrug and alcohol dependence
- 2013
Designer drugs: a medicinal chemistry perspective
- Chemistry, BiologyAnnals of the New York Academy of Sciences
- 2012
This review describes how clandestine chemists used the principles of medicinal chemistry to design molecules that elicit the effects of opioids, amphetamine and analogs, cannabinoids, and phencyclidine analogs while circumventing the law.
Nephrotoxicity of recreational party drugs
- MedicineNephrology
- 2012
N‐benzylpiperazine (BZP) is the active ingredient in recreational ‘party’ pills with a stimulant, euphoric mechanism of action akin to that of 3,4‐methylenedioxymethamphetamine (MDMA or ecstasy).…
Acute Kidney Injury Associated with Synthetic Cannabinoid Use — Multiple States, 2012
- MedicineMMWR. Morbidity and mortality weekly report
- 2013
The results of the investigation determined that no single SC brand or compound explained all 16 cases, and public health practitioners, poison center staff members, and clinicians should be aware of the potential for renal or other unusual toxicities in users of SC products and should ask about SC use in cases of unexplained AKI.
Synthetic cannabinoid use associated with acute kidney injury*
- MedicineClinical toxicology
- 2013
A previously healthy 26-year-old male presented to the emergency department with one day of abdominal pain, nausea, vomiting and lower back pain and was discharged after six days in the hospital with AKI of unknown etiology and serum creatinine of 3.09 mg/dL.
Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management.
- MedicineBritish journal of anaesthesia
- 2006
An overview of MDMA pharmacology and acute toxicity will be given followed by a plan for clinical management of patients with acute MDMA toxicity.
Bath salt intoxication causing acute kidney injury requiring hemodialysis
- BiologyHemodialysis international. International Symposium on Home Hemodialysis
- 2012
Traditional bath salts contain a combination of inorganic salts like Epsom salts, table salt, baking soda, sodium metaphosphate, and borax that have cleansing properties and act as central nervous system stimulants with high additive and abuse potential.