Nephrotic hyperlipidemia: primary abnormalities in both lipoprotein catabolism and synthesis.

@article{Kaysen1992NephroticHP,
  title={Nephrotic hyperlipidemia: primary abnormalities in both lipoprotein catabolism and synthesis.},
  author={George Alan Kaysen},
  journal={Mineral and electrolyte metabolism},
  year={1992},
  volume={18 2-5},
  pages={212-6}
}
One of the most prominent manifestations of the nephrotic syndrome is hyperlipidemia. Lipoprotein synthesis is increased and catabolism is reduced in nephrotic patients and animals. The observation that infusion of either albumin or dextran reduces lipid levels suggests that oncotic pressure (pi) may regulate lipogenesis. It has been postulated that prolonged plasma half-life of lipoproteins in nephrosis is a consequence of saturation of catabolic sites and is secondary to the hyperlipidemia… CONTINUE READING
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