Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.

  title={Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway.},
  author={Yan Wang and Mengzhen Niu and Sha Yin and F. Zhang and Ruizan Shi},
  journal={Pharmacological reports : PR},
  volume={70 5},
  • Yan Wang, Mengzhen Niu, +2 authors Ruizan Shi
  • Published 2018
  • Chemistry, Medicine
  • Pharmacological reports : PR
  • BACKGROUND To evaluate the protective effect of nebivolol against kidney damage and elucidate the underlying mechanism in a two-kidney, one-clip (2K1C) rat model. METHODS 2K1C rats were obtained by clipping left renal artery of male Wistar rats and were considered hypertensive when systolic blood pressure (SBP) was ≥160mmHg 4 weeks after surgery. The 2K1C hypertensive rats were divided into untreated, nebivolol (10mg/kg, ig), and atenolol (80mg/kg, ig) treatment groups. The treatments lasted… CONTINUE READING
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