Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats

@article{Hamid2012NephroprotectiveEO,
  title={Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats},
  author={Zariyantey Abdul Hamid and Siti Balkis Budin and Ng Wen Jie and Asmah Hamid and Khairana Husain and Jamaludin Mohamed},
  journal={Journal of Zhejiang University SCIENCE B},
  year={2012},
  volume={13},
  pages={176-185}
}
Paracetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. In this study, the effects of ethyl acetate extract of Zingiber zerumbet rhizome [200 mg per kg of body weight (mg/kg) and 400 mg/kg] on PCM-induced nephrotoxicity were examined. Rats were divided into five groups containing 10 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), PCM alone (750 mg/kg… CONTINUE READING
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