Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein

@inproceedings{Cavalcante2019NephropathyIH,
  title={Nephropathy in Hypertensive Animals Is Linked to M2 Macrophages and Increased Expression of the YM1/Chi3l3 Protein},
  author={Paula Andr{\'e}a Malveira Cavalcante and Natalia Alenina and Alexandre Budu and Leandro Ceotto Freitas-Lima and Tha{\'i}s Alves-Silva and Juan Sebastian Henao Agudelo and Fatimunnisa Qadri and Niels Olsen Saraiva C{\^a}mara and Michael Bader and Ronaldo C Araujo},
  booktitle={Mediators of inflammation},
  year={2019}
}
Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of hypertension. Bone marrow cells were isolated from the femurs and tibia of male FVB/N (control) and transgenic hypertensive animals that overexpressed the rat form of… CONTINUE READING

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