Nephrogenic syndrome of inappropriate antidiuresis.

  title={Nephrogenic syndrome of inappropriate antidiuresis.},
  author={Brian J. Feldman and Stephen M. Rosenthal and Gabriel A. Vargas and Raymond G. Fenwick and Eric A Huang and Mina Matsuda-Abedini and Robert H. Lustig and Robert S. Mathias and Anthony A. Portale and Walter Miller and Stephen E. Gitelman},
  journal={The New England journal of medicine},
  volume={352 18},
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia. We describe two infants whose clinical and laboratory evaluations were consistent with the presence of SIADH, yet who had undetectable arginine vasopressin (AVP) levels. We hypothesized that they had gain-of-function mutations in the V2 vasopressin receptor (V2R). DNA sequencing of each patient's V2R gene (AVPR2) identified missense mutations in both, with resultant changes in codon 137 from… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 119 extracted citations


Publications referenced by this paper.
Showing 1-10 of 24 references

The use of oral urea in the treatment of chronic syndrome of inappropriate antidiuretic hormone secretion ( SIADH ) in children

  • EA Huang, DH Geller, SE Gitelman
  • J Mol Endocrinol
  • 2002

Melanocor - tin4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

  • J Stables, S Scott, S Brown
  • J Clin Invest
  • 2000

Devel - opment of a dual glowsignal firefly and Renilla luciferase assay reagent for the analysis of G - protein coupled receptor signalling

  • CE Fluck, JW Martens, FA Conte, WL Miller
  • J Recept Signal Transduct Res
  • 1999

Similar Papers

Loading similar papers…