Nephroblastomatosis and loss of WT1 expression associated with trisomy 13

  title={Nephroblastomatosis and loss of WT1 expression associated with trisomy 13},
  author={Frank Traub and Karin Sickmann and Mathewos Tessema and L. Wilkens and Hans Kreipe and Kenji Kamino},
  journal={Virchows Archiv},
Trisomy 13 (Patau's syndrome) is a rare finding in newborns. The life span of babies affected by this chromosome abnormality is severely shortened, and multiple, partly severe malformations occur. In this study, we report on an unborn with trisomy 13 (artificially aborted on the 24th week) which showed, among other typical deformities, bilateral nephrogenic rests (nephroblastomatosis). Using molecular analysis, a loss of Wilms' tumor gene 1 (WT1) transcript and a biallelic expression of insulin… CONTINUE READING

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