Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit?

@article{Guerrot2008NephroangiosclerosisIC,
  title={Nephroangiosclerosis in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: is NOTCH3 mutation the common culprit?},
  author={Dominique Guerrot and Arnaud François and J F Boffa and Nada Boulos and M{\'e}lanie Hanoy and Bruno Legallicier and Aude Triquenot-Bagan and Lucie Guyant-Mar{\'e}chal and Annie Laqu{\'e}rriere and Caroline Fr{\'e}guin-Bouilland and Pierre Ronco and Michel Godin},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={2008},
  volume={52 2},
  pages={340-5}
}
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a systemic arterial disease characterized by impairment of vascular smooth muscle cell structure and function related to NOTCH3 mutations. Pathological findings include pathognomonic granular osmiophilic material (GOM) deposition with nonspecific hyalinization within the artery wall in a variety of tissues. The main clinical presentation is iterative strokes in young adults despite the lack… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Characteristic features of in vivo skin microvascular reactivity in CADASIL.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2007

Interactions contributing to kidney blood flow autoregulation.

Current opinion in nephrology and hypertension • 2007

The archeypal R 90 C CADASILNOTCH 3 mutation retains NOTCH 3 unction in vivo

M Monet, V Domenga, B Lemaire
Hum Mol Genet • 2007

Notch 3 ectodoain is a major component of granular osmiophilic material GOM ) in CADASIL

A Ishiko, A Shimizu, E Nagata
Acta Neuropathol ( Berl ) • 2006

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