Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

@article{Rantanen2002NephrinTM,
  title={Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.},
  author={Maija Rantanen and Tuula Palm{\'e}n and Anu P{\"a}t{\"a}ri and Heikki Ahola and Sanna Lehtonen and Eva {\AA}str{\"o}m and Thomas Floss and Franz Vauti and Wolfgang Wurst and Patrizia Ruiz and Dontscho Kerjaschki and Harry Holth{\"o}fer},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2002},
  volume={13 6},
  pages={1586-94}
}
The molecular mechanisms maintaining glomerular filtration barrier are under intensive study. This study describes a mutant Nphs1 mouse line generated by gene-trapping. Nephrin, encoded by Nphs1, is a structural protein of interpodocyte filtration slits crucial for formation of primary urine. Nephrin(trap/trap) mutants show characteristic features of proteinuric disease and die soon after birth. Morphologically, fibrotic glomeruli with distorted structures and cystic tubular lesions were… CONTINUE READING