Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice

  title={Neovascularization and angiogenic gene expression following chronic arsenic exposure in mice},
  author={Nicole V. Soucy and Debra Mayka and Linda R. Klei and Antonia A. Nemec and John Anthony Bauer and Aaron Barchowsky},
  journal={Cardiovascular Toxicology},
Exposure to arsenic in drinking water increases incidence of cardiovascular diseases. However, the basic mechanisms and genetic changes that promote these diseases are unknown This study investigated the effects of chronic arsenic exposure on vessel growth and expression of angiogenic and tissue remodeling genes in cardiac tissues. Male mice were exposed to low to moderately high levels of arsenite (Aslll) for 5, 10, or 20 wk in their drinking water. Vessel growth in Matrigel implants was… CONTINUE READING


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