Neovascularization and Metastasis in Mice Deletion of Laminin-8 Results in Increased Tumor

@inproceedings{Zhou2004NeovascularizationAM,
  title={Neovascularization and Metastasis in Mice Deletion of Laminin-8 Results in Increased Tumor},
  author={Zhongjun Zhou and Masayuki Doi and Jianming Wang and Renhai Cao and Baohua Liu and K. M. Chan and Jarkko Kortesmaa and Lydia Sorokin and Yihai Cao and K. Tryggvason},
  year={2004}
}
Laminin-8 ( 4 1 1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin 4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The… CONTINUE READING