Neoplastic transformation in vitro induced by low doses of 232 MeV protons.

@article{Elmore2005NeoplasticTI,
  title={Neoplastic transformation in vitro induced by low doses of 232 MeV protons.},
  author={Eugene Elmore and X Lao and Myungseo Ko and Steven Rightnar and Gregory Nelson and Jl Redpath},
  journal={International journal of radiation biology},
  year={2005},
  volume={81 4},
  pages={291-7}
}
The aim was to define the dose--response curve for high-energy proton-induced neoplastic transformation in vitro. The HeLa x skin fibroblast human hybrid cell assay was used to determine the frequency of neoplastic transformation following doses of 232 MeV protons (mean linear energy transfer, LET=0.44 keV microm(-1)) in the range 5-600 mGy. Proton irradiations were carried out at the Loma Linda University Proton Treatment Facility, CA, USA. The data indicate no evidence for induction of… CONTINUE READING