Neoplastic transformation by quartz in the BALB/3T3/A31-1-1 cell line and the effects of associated minerals.

@article{Saffiotti1995NeoplasticTB,
  title={Neoplastic transformation by quartz in the BALB/3T3/A31-1-1 cell line and the effects of associated minerals.},
  author={Umberto Saffiotti and Nazia Aziz Ahmed},
  journal={Teratogenesis, carcinogenesis, and mutagenesis},
  year={1995},
  volume={15 6},
  pages={
          339-56
        }
}
Quartz, the most common form of crystalline silica, was tested quantitatively for neoplastic transformation in the mouse embryo cell line, BALB/3T3/A31-1-1. Five quartz dust samples of respirable size [Min-U-Sil 5 (MQZ); hydrofluoric-acid-etched MQZ (HFMQZ); Chinese standard quartz (CSQZ); DQ12; and F600] all induced significant levels of neoplastic transformation, showing dose-dependent increases in the frequency of morphologically transformed foci at lower tested doses and a plateau level of… CONTINUE READING
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