Neoplastic transformation and induction of H+,K+-adenosine triphosphatase by N-methyl-N′-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line

@article{Shimokawa2007NeoplasticTA,
  title={Neoplastic transformation and induction of H+,K+-adenosine triphosphatase by N-methyl-N′-nitro-N-nitrosoguanidine in the gastric epithelial RGM-1 cell line},
  author={Osamu Shimokawa and Hirofumi Matsui and Yumiko N Nagano and Tsuyoshi Kaneko and Takeshi Shibahara and Akira Nakahara and Ichinosuke Hyodo and Akinori Yanaka and Hideyuki J. Majima and Yukio Nakamura and Yasushi Matsuzaki},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2007},
  volume={44},
  pages={26-30}
}
N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induces gastric cancer in animal models. We established an MNNG-induced mutant of the rat murine RGM-1 gastric epithelial cell line, which we named RGK-1, that could be used as an in vitro model of gastric cancer. This cell line showed signs of neoplasia and transformation, in that it lost contact inhibition and… CONTINUE READING