Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial-mesenchymal transition.

@article{Luo2012NeoplasticSC,
  title={Neoplastic spindle cells in nasopharyngeal carcinoma show features of epithelial-mesenchymal transition.},
  author={Wei-ren Luo and Xiao-yi Chen and Si-yi Li and Ai-bing Wu and Kai-Tai Yao},
  journal={Histopathology},
  year={2012},
  volume={61 1},
  pages={113-22}
}
AIM To investigate whether the neoplastic spindle cells in nasopharyngeal carcinoma (NPC) are associated with the process of epithelial-mesenchymal transition (EMT). METHODS AND RESULTS We used immunohistochemistry to analyse the expression of cytokeratin, E-cadherin, β-catenin, vimentin, fibronectin, Snail1, Slug and aldehyde dehydrogenase 1 (ALDH1) in 115 cases of NPC in which there were neoplastic spindle cells; in 47 cases a neoplastic squamous cell component was also present. There was… CONTINUE READING

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