Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum.

@article{Jass2000NeoplasticPO,
  title={Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum.},
  author={Jereny R Jass and Haruhiko Iino and Andrew Ruszkiewicz and Dorothy Painter and Michael J. Solomon and David J Koorey and Danny Cohn and Kevin Furlong and M. D. Walsh and Juan A Palazzo and Tina Bocker Edmonston and Richard Fishel and Joanne A. Young and Barbara A. Leggett},
  journal={Gut},
  year={2000},
  volume={47 1},
  pages={43-9}
}
AIM Colorectal cancer has been described in association with hyperplastic polyposis but the mechanism underlying this observation is unknown. The aim of this study was to characterise foci of dysplasia developing in the polyps of subjects with hyperplastic polyposis on the basis of DNA microsatellite status and expression of the DNA mismatch repair proteins hMLH1, hMSH2, and hMSH6. MATERIALS AND METHODS The material was derived from four patients with hyperplastic polyposis and between one… CONTINUE READING