Neoplastic progression in short-segment Barrett's oesophagus is associated with impairment of chemical clearance, but not inadequate acid suppression by proton pump inhibitor therapy.

@article{Frazzoni2014NeoplasticPI,
  title={Neoplastic progression in short-segment Barrett's oesophagus is associated with impairment of chemical clearance, but not inadequate acid suppression by proton pump inhibitor therapy.},
  author={Marzio Frazzoni and Helga Bertani and Rita Luisa Conigliaro and Leonardo Frazzoni and Luisa Losi and Gianluigi Melotti},
  journal={Alimentary pharmacology & therapeutics},
  year={2014},
  volume={40 7},
  pages={835-42}
}
BACKGROUND Pathophysiological mechanisms associated with neoplastic progression in patients with short-segment Barrett's oesophagus (SSBO), who represent the vast majority of the Barrett population, have not been defined. AIM To evaluate pathophysiological characteristics of patients with SSBO and dysplasia detected at 3-year surveillance endoscopy (incident dysplasia). METHODS Patients with SSBO underwent impedance-pH monitoring during heartburn-suppressing PPI therapy. Fifteen patients… CONTINUE READING
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