Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR

Abstract

The interferon-inducible, double-stranded RNA (dsRNA)-activated protein kinase, PKR, plays key roles in regulation of cell growth and differentiation, and has been postulated as a tumor suppressor. Downstream effectors of PKR include the translation initiation factor, eIF2α, and the transcription factor, NF-κB. We found elevated levels of PKR protein, dsRNA… (More)
DOI: 10.1038/sj.onc.1205987

Topics

5 Figures and Tables