Neoplastic meningitis

@article{Gleissner2006NeoplasticM,
  title={Neoplastic meningitis},
  author={Beate Gleissner and Marc C Chamberlain},
  journal={The Lancet Neurology},
  year={2006},
  volume={5},
  pages={443-452}
}
Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?
TLDR
The overall prevalence of the presence of false-positive meningeal contrast enhancement is low (< 1%) and not associated with specific imaging patterns, and it is hypothesized that there is a possible relationship between immunotherapy and ‘pseudomeningeosis’.
Leptomeningeal Metastasis: The Role of Cerebrospinal Fluid Diagnostics
TLDR
CSF examination is helpful to detect leptomeningeal metastasis since the diagnosis can be challenging especially when MRI is negative, and CSF cytological investigation is mandatory whenever lepto-metastatic metastasis is suspected, even when CSF cell count is normal.
Neoplastic Meningitis and Paraneoplastic Syndromes.
Cerebrospinal fluid approach on neuro-oncology.
  • H. Gomes
  • Medicine, Biology
    Arquivos de neuro-psiquiatria
  • 2013
TLDR
New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.
Association of MRI findings with clinical characteristics and prognosis in patients with leptomeningeal carcinomatosis from non-small cell lung cancer
TLDR
Positive MRI findings suggests heavier disease burden than negative MRI findings in patients with LMC who died of a central nervous system cause, and spina bifida found in patientswith LMC correlate with cauda equina symptoms.
Meningeal carcinomatosis from bladder cancer: A case report and review of the literature.
TLDR
A 66-year-old Japanese male patient was referred to Saitama Medical University International Medical Center for treatment of bladder cancer and diagnosed with meningeal carcinomatosis (MC), but his condition rapidly worsened and he succumbed to the disease 14 days after the diagnosis.
The role of intra-cerebrospinal fluid treatment and prophylaxis in patients with solid tumors.
TLDR
Clinical situations in which treatment or chemoprophylaxis of CNS metastases and NM from breast or lung cancer may play an important role are discussed and potential clinical trials to assess these assumptions are proposed.
CEREBROSPINAL FLUID CYTOLOGY IN CANCER PATIENTS: AN INSTITUTIONAL STUDY WITH 5394 CASES -
TLDR
Cytological examinations of the CSF played a decisive role in the diagnosis of LC, with acute lymphoblastic leukemia the commonest malignancy infiltrating CSF in both children and adults.
Neoplastic meningitis due to colorectal cancer
TLDR
A rare case of neoplastic meningitis in a 54-year-old male with a history of colorectal cancer who first noticed a loss of sensation in his left thigh along with back pain and died 5 months after the diagnosis.
Management of leptomeningeal metastases in non-small cell lung cancer
TLDR
Therapeutic options for management of LM in NSCLC patients with or without genetic mutations are reviewed to improve or stabilize neurologic status, improve quality of life, and prolong survival while limiting the toxicity of chemotherapeutic regimens.
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