Neoplastic meningitis

@article{Gleissner2006NeoplasticM,
  title={Neoplastic meningitis},
  author={Beate Gleissner and Marc C Chamberlain},
  journal={The Lancet Neurology},
  year={2006},
  volume={5},
  pages={443-452}
}
BACKGROUND Neoplastic meningitis (NM) is a common problem in neuro-oncology, occurring in approximately 5% of all patients with cancer. REVIEW SUMMARY Notwithstanding frequent focal signs and symptoms in NM, NM is a disease affecting the entire neuraxis, and therefore staging and treatment need encompass all cerebrospinal fluid (CSF) compartments. RESULTS Central nervous system (CNS) staging of NM includes contrast-enhanced cranial computed tomography (CE-CT) or magnetic resonance imaging… Expand
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68 Citations
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68 Citations

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CSF examination is helpful to detect leptomeningeal metastasis since the diagnosis can be challenging especially when MRI is negative, and CSF cytological investigation is mandatory whenever lepto-metastatic metastasis is suspected, even when CSF cell count is normal. Expand
Neoplastic Meningitis and Paraneoplastic Syndromes.
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Diagnosis of NM largely depends on documenting circulating tumor cells in the cerebrospinal fluid and/or leptomeningeal and nodular enhancement on contrast-enhanced MR imaging of the brain or axial spine. Expand
Cerebrospinal fluid approach on neuro-oncology.
  • H. Gomes
  • Medicine
  • Arquivos de neuro-psiquiatria
  • 2013
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New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment. Expand
Association of MRI findings with clinical characteristics and prognosis in patients with leptomeningeal carcinomatosis from non-small cell lung cancer
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Positive MRI findings suggests heavier disease burden than negative MRI findings in patients with LMC who died of a central nervous system cause, and spina bifida found in patientswith LMC correlate with cauda equina symptoms. Expand
Meningeal carcinomatosis from bladder cancer: A case report and review of the literature.
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A 66-year-old Japanese male patient was referred to Saitama Medical University International Medical Center for treatment of bladder cancer and diagnosed with meningeal carcinomatosis (MC), but his condition rapidly worsened and he succumbed to the disease 14 days after the diagnosis. Expand
The role of intra-cerebrospinal fluid treatment and prophylaxis in patients with solid tumors.
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Clinical situations in which treatment or chemoprophylaxis of CNS metastases and NM from breast or lung cancer may play an important role are discussed and potential clinical trials to assess these assumptions are proposed. Expand
CEREBROSPINAL FLUID CYTOLOGY IN CANCER PATIENTS: AN INSTITUTIONAL STUDY WITH 5394 CASES -
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Cytological examinations of the CSF played a decisive role in the diagnosis of LC, with acute lymphoblastic leukemia the commonest malignancy infiltrating CSF in both children and adults. Expand
Neoplastic meningitis due to colorectal cancer
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A rare case of neoplastic meningitis in a 54-year-old male with a history of colorectal cancer who first noticed a loss of sensation in his left thigh along with back pain and died 5 months after the diagnosis. Expand
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