Neoplastic lesions of questionable significance to humans.

@article{Alison1994NeoplasticLO,
  title={Neoplastic lesions of questionable significance to humans.},
  author={Roger H. Alison and Charles Chabert Capen and Donna Prentice},
  journal={Toxicologic pathology},
  year={1994},
  volume={22 2},
  pages={
          179-86
        }
}
Many compounds giving a positive result in animal carcinogenicity studies through mechanisms involving secondary carcinogenesis pose little or no risk to humans. This article provides an overview of current understanding, with particular reference to renal tumors in male rats with alpha 2mu-globulin nephropathy, urinary bladder neoplasia in rodents, mesovarian leiomyomas induced in rats by beta 2-receptor stimulants, carcinoid tumors in the rodent stomach induced by prolonged suppression of… CONTINUE READING
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