Neoplastic fever: a neglected paraneoplastic syndrome

  title={Neoplastic fever: a neglected paraneoplastic syndrome},
  author={Jason A. Zell and Jae C. Chang},
  journal={Supportive Care in Cancer},
Neoplastic fever, a paraneoplastic syndrome caused by cancer itself, represents a diagnostic challenge for the clinician and is an important issue in supportive oncology. Timely recognition of this febrile condition by differentiating it from other cancer-associated fevers, such as infection and drug reaction, is essential for effective patient management. Although the pathophysiology of neoplastic fever is not well understood, it is suspected to be cytokine mediated. In clinical practice, when… 

Naproxen test for neoplastic fever may reduce suffering.

An early trial of naproxen is inexpensive and, in patients who can tolerate NSAIDs, may provide good control for NF, which can lead to unnecessary and prolonged hospitalization in patients near the end of their life.

Fever in Patients With Cancer.

The utility of acute-phase reactants, such as erythrocyte sedimentation rate, C-reactive protein, and procalcitonin, along with a nonsteroidal anti-inflammatory drug challenge should be further evaluated as adjunct tools for the workup of fever in patients with cancer.

Neoplastic fever in patients with bone and soft tissue sarcoma.

Naproxen may be effective for treating neoplastic fever in patients with bone and soft tissue sarcoma; however, radical tumor treatment may have to be considered to achieve permanent lysis of the fever.

Malignant causes of fever of unknown origin.

The presence of fever in malignancy usually indicates infection, though transfusion, thrombosis and drugs are also culprits. However, particularly in some tumour types, fever can also be a

Fever of Undetermined Origin During Neoadjuvant Chemoradiotherapy of Gastroesophageal Junction Adenocarcinoma Due to Radiation-induced Liver Disease

This case illustrates that RILD can sometimes present as prolonged fever and clinicians should be cognizant of radiation necrosis as a potential treatment complication that should be confirmed with a biopsy to avoid missing the chance at potential cure.

Fever of unknown origin: a clinical mask of malignant peritoneal mesothelioma

In this patient, fever of unknown origin was a clinical mask of mesothelioma and the diagnostic process was focused on infections and collagen-vascular diseases since they are the most common causes of the systemic inflammatory response syndrome.

Neoplastic Fever: All who Shiver are not Infected.

The case of previously healthy 14 years old male who presented high grade fever and headache is reported, suggestive of a central nervous system neoplasm, and neoplastic fever as cause of acute febrile illness is considered as a remote possibility.

Pancreatic carcinoma masked as fever of unknown origin

Pancreatic adenocarcinoma could manifest as neoplastic fever at the time of diagnosis and if the tumor is resectable, surgical resection is a safe and curative form of therapy not only for the fever but also for the original carcinoma.



Neoplastic fever. A proposal for diagnosis.

F fever is a very common problem in patients receiving cytotoxic chemotherapy and can be caused not only by infection but also by cancer itself, it is crucial for the clinician to be able to establish a definite diagnosis of neoplastic fever during management of cancer.

Neoplastic fever.

In the future, cytokine antagonists may have a role in managing neoplastic fever, but, until their actions are better understood, nonsteroidal anti-inflammatory drugs remain the medication of choice if standard antipyretics have failed.

The Clinical Significance of Fever in Hodgkin's Disease

Specific parameters which might help in differentiating fever due to infection (FI) from fever apparently due to the disease itself (FHD) are found.

Utility of naproxen in the differential diagnosis of fever of undetermined origin in patients with cancer.

The effect of naproxen on fever in patients with advanced gynecologic malignancies.

Naproxen is clinically useful in the palliation of fever-related symptoms in gynecologic oncology patients with suspected neoplastic fever and may also allow the limitation of extensive fever workups and prolonged empiric antibiotic therapy in these patients, and prevent delays in systemic therapy or supportive care.

Fever of unknown origin

Neoplastic fever responds to the treatment of an adequate dose of naproxen.

  • J. C. ChangH. Gross
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1985
Naproxen has a definite and effective antipyretic activity against neoplastic fever although it may recur as the drug is discontinued, and may be a useful adjunctive agent in patients with neoplastics fever for a short-term symptomatic relief.

Antipyretic effect of naproxen and corticosteroids on neoplastic fever.

  • J. C. Chang
  • Medicine
    Journal of pain and symptom management
  • 1988

From prolonged febrile illness to fever of unknown origin: the challenge continues.

Prolonged febrile illnesses remain a diagnostic challenge, especially in those with episodic fevers, and noninfectious inflammatory diseases emerge as the most prevalent diagnostic category.

Cyclo-oxygenase II inhibitors in the treatment of neoplastic fever

Rofecoxib, a cyclooxygenase-II inhibitor, is substituted for naproxen in patients with a previous history of, or a newly diagnosed, neoplastic fever in whom naproxens was relatively contraindicated.