Neoplastic fever: a neglected paraneoplastic syndrome

@article{Zell2005NeoplasticFA,
  title={Neoplastic fever: a neglected paraneoplastic syndrome},
  author={Jason A. Zell and Jae C. Chang},
  journal={Supportive Care in Cancer},
  year={2005},
  volume={13},
  pages={870-877}
}
Neoplastic fever, a paraneoplastic syndrome caused by cancer itself, represents a diagnostic challenge for the clinician and is an important issue in supportive oncology. Timely recognition of this febrile condition by differentiating it from other cancer-associated fevers, such as infection and drug reaction, is essential for effective patient management. Although the pathophysiology of neoplastic fever is not well understood, it is suspected to be cytokine mediated. In clinical practice, when… 

Naproxen test for neoplastic fever may reduce suffering.

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Fever in Patients With Cancer.

The utility of acute-phase reactants, such as erythrocyte sedimentation rate, C-reactive protein, and procalcitonin, along with a nonsteroidal anti-inflammatory drug challenge should be further evaluated as adjunct tools for the workup of fever in patients with cancer.

Neoplastic fever in patients with bone and soft tissue sarcoma.

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Malignant causes of fever of unknown origin.

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In this patient, fever of unknown origin was a clinical mask of mesothelioma and the diagnostic process was focused on infections and collagen-vascular diseases since they are the most common causes of the systemic inflammatory response syndrome.

Neoplastic Fever: All who Shiver are not Infected.

The case of previously healthy 14 years old male who presented high grade fever and headache is reported, suggestive of a central nervous system neoplasm, and neoplastic fever as cause of acute febrile illness is considered as a remote possibility.

Pancreatic carcinoma masked as fever of unknown origin

Pancreatic adenocarcinoma could manifest as neoplastic fever at the time of diagnosis and if the tumor is resectable, surgical resection is a safe and curative form of therapy not only for the fever but also for the original carcinoma.
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