Neoplastic cell transformation by high-LET radiation: molecular mechanisms.

  title={Neoplastic cell transformation by high-LET radiation: molecular mechanisms.},
  author={Tracy C. H. Yang and L M Craise and Mantong Mei and Cornelius A. Tobias},
  journal={Advances in space research : the official journal of the Committee on Space Research},
  volume={9 10},
Experimental data on molecular mechanisms are essential for understanding the bioeffects of radiation and for developing biophysical models, which can help in determining the shape of dose-response curves at very low doses, e.g., doses less than 1 cGy. Although it has been shown that ionizing radiation can cause neoplastic cell transformation directly, that high-LET heavy ions in general can be more effective than photons in transforming cells, and that the radiogenic cell transformation is a… CONTINUE READING


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