Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B

  title={Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B},
  author={Radhakrishnan Vishnubalaji and Ramesh Elango and Mashael Al-toub and Muthurangan Manikandan and Ammar Cherkess Al-Rikabi and Linda Harkness and Nicholas Ditzel and Muhammad Atteya and Rola N. Hamam and Musaad Alfayez and Abdullah M. Aldahmash and Moustapha Kassem and Nehad M Alajez},
  booktitle={Scientific Reports},
Bone marrow stromal (Mesenchymal) stem cells (MSCs) are multipotent bone cells capable of differentiating into mesoderm-type cells, such as osteoblasts and adipocytes. Existing evidence suggests that transformation of MSCs gives rise to sarcoma. In order to identify the molecular mechanism leading to spontaneous transformation of human bone marrow MSCs (hBMSCs), we performed comprehensive microRNA (miRNA) and mRNA profiling in the transformed hBMSC-Tum line compared to the parental clone. As a… CONTINUE READING
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Molecular profiling of ALDH1(+) colorectal cancer stem cells reveals preferential activation of MAPK, FAK, and oxidative stress pro-survival signalling pathways

R Vishnubalaji
  • Oncotarget 9(17),
  • 2018

Bone morphogenetic protein 2 (BMP2) induces growth suppression and enhances chemosensitivity of human colon cancer cells

R Vishnubalaji
  • Cancer Cell Int 16,
  • 2016