Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses.

  title={Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses.},
  author={Arya Biragyn and Dan L. Longo},
  journal={Seminars in cancer biology},
  volume={22 1},
Metastatic cancer is usually an incurable disease. Cancers have a broad repertoire of subversive tactics to defeat the immune system. They mimic self, they down-regulate MHC molecules so that T cells are blind to their presence, they interfere with antigen presentation, and they produce factors that can kill T cells or paralyze their response to antigens. Furthermore, the same powerful machinery designed to prevent harmful autoimmune responses is also acting to protect cancers. In particular… CONTINUE READING
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