Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination
@article{Murthy1979NeoplasmsIR, title={Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination}, author={A. Murthy and J. R. Baker and E. Smith and E. Zepp}, journal={International Journal of Cancer}, year={1979}, volume={23} }
In projected 485‐day studies, Fischer 344 rats and C57BL/6 mice were fed 0.58% butylurea and 0.50% sodium nitrite mixed in the diet separately or in combination. The number and type of neoplasms were not significantly increased in either species receiving butylurea or sodium nitrite only. Feeding the two chemicals simultaneously induced neoplasms of the lung, Zymbal's gland, forestomach, intestine and hemopoietic tissues in rats, and malignant lymphomas in mice. The increased incidence of… CONTINUE READING
Topics from this paper
6 Citations
Chronic toxicity of sodium nitrite in the male F344 rat.
- Chemistry, Medicine
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 1989
- 29
Tumors in control hamsters, rats, and mice: literature tabulation.
- Medicine
- Critical reviews in toxicology
- 1982
- 55
Ingested nitrate and nitrite and stomach cancer risk: an updated review.
- Chemistry, Medicine
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2012
- 190
- PDF
A carcinogenic potency database of the standardized results of animal bioassays
- Biology, Medicine
- Environmental health perspectives
- 1984
- 459
- PDF
References
SHOWING 1-10 OF 19 REFERENCES
Induction of liver and lung tumours in rats by the simultaneous administration of sodium nitrite and morpholine.
- Chemistry, Medicine
- Food and cosmetics toxicology
- 1973
- 30
Nitrosamide formation in vivo: induction of lung adenomas in Swiss mice by concurrent feeding of nitrite and methylurea or ethylurea.
- Chemistry, Medicine
- Journal of the National Cancer Institute
- 1972
- 29
- PDF
Tumor induction in rats by feeding heptamethyleneimine and nitrite in water.
- Medicine
- Cancer research
- 1975
- 32
- PDF
Multiple carcinogenic effects of the ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.
- Medicine
- Cancer research
- 1974
- 20
- PDF
Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrousourea precursors to adult rats.
- Chemistry, Medicine
- Food and cosmetics toxicology
- 1975
- 17
Intestinal tumors in mice treated with a single injection of N-nitroso-N-butylurea.
- Medicine
- Cancer research
- 1975
- 18
Malignant Tumours of Liver and Lung in Rats fed Aminopyrine or Heptamethyleneimine together with Nitrite
- Medicine
- Nature
- 1973
- 80
Carcinogenicity of nitrosation products of ephedrine, sarcosine, folic acid, and creatinine.
- Chemistry, Medicine
- Cancer research
- 1975
- 44
- PDF
Weitere Versuche zur Tumor-Induktion durch orale Applikation niederer Dosen von N-Methylbenzylamin und Natriumnitrit
- Zeitschrift für Krebsforschung und Klinische Onkologie
- 2004
- 6