Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination

  title={Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination},
  author={A. Murthy and J. R. Baker and E. Smith and E. Zepp},
  journal={International Journal of Cancer},
  • A. Murthy, J. R. Baker, +1 author E. Zepp
  • Published 1979
  • Medicine
  • International Journal of Cancer
  • In projected 485‐day studies, Fischer 344 rats and C57BL/6 mice were fed 0.58% butylurea and 0.50% sodium nitrite mixed in the diet separately or in combination. The number and type of neoplasms were not significantly increased in either species receiving butylurea or sodium nitrite only. Feeding the two chemicals simultaneously induced neoplasms of the lung, Zymbal's gland, forestomach, intestine and hemopoietic tissues in rats, and malignant lymphomas in mice. The increased incidence of… CONTINUE READING
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